Clobetasol Propionate is a topical corticosteroid (an analogue of prednisolone) having a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity, used in treatment of psoriasis,eczema and other topical dermatological purposes.It act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination of clobetasol propionate as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers 14 analytical methods including spectrophotometric methods like spectrophotometry through charge transfer complexation; chromatographic method including HPLC, LC-MS,HPLC-UV-MS and miscellaneous method like linear sweep adsorptive stripping voltammetry were reported. The application of these methods for the determination of clobetasol propionate in pharmaceutical dosage forms and biological samples has also been discussed.
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